The ESPR Infection, Inflammation, Immunology and Immunisation (I4) Section
Welcome to the Infection, Inflammation, Immunology and Immunisation (I4) Section of the European Society for Paediatric Research (ESPR)
The I4 section promotes research on neonatal infection, inflammation, immunology and immunisation and its translation into patient care. This is achieved by exchange of ideas, discussions and collaborations among researchers and experts in the field, by organizing parallel sessions, workshops and courses during the annual ESPR conference (EAPS and JENS) as well as by setting up collaborative writing groups and generating new ideas for clinical trials. We welcome all neonatologists, pediatricians, researchers, and nurses interested in the topic to attend our meetings, and contribute to the activities and future development of the section.
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Our objectives
The objectives of the section on Infection, Inflammation, Immunology and Immunisation (I4) are to:
• Bring together researchers and clinicians interested in the field;
• Serve as an international platform for collaborative research and education;
• Provide best evidence and consensus on topics of importance;
• Collaborate with other groups within ESPR, other societies and partners in and outside Europe;
• Integrate of junior clinicians and scientists, and foster the next generation of researchers. -
Meet the Section Council
Eric Giannoni
Neonatologist, MD
Section chair since 2022
Associate Professor
Lausanne University Hospital,
SwitzerlandEleanor Molloy
Neonatologist, MD PhD
Council member since 2018
Chair & Professor of Paediatrics, Trinity College Dublin, IrelandIrwin Reiss
Neonatologist, MD PhD
Council member since 2018
Professor of Neonatology
Erasmus MC, Rotterdam
The NetherlandsFleur Keij
Resident in Pediatrics, MD -
PhD candidate
Junior council member since 2018
Erasmus MC-Sophia Children's Hospital, Rotterdam, the NetherlandsJan Mazela
Neonatologist, MD PhD
Council member since 2018Professor, Medical Director
Department of Neonatology
Laboratory of Microbiome and Nutrition, National Coordinator for Neonatal Transport, Poznan University of Medical Sciences, Poland -
Current & future projects of the section
We are writing systematic reviews on neonatal infection and sepsis, focusing on organ dysfunction, core outcomes and diagnostic tools.
The NESCOS (Neonatal Sepsis Core Outcomes Set) led by Prof Declan Devane (Galway University, Ireland) aims at identifying the most important outcomes in trials looking at treatments for neonatal sepsis. The international expert steering committee has been established and a Delphi process is underway.
The section is developing a new training module, within the Neonatal Online Training & Education (NOTE) Programme.
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Upcoming meetings of the section
Online meetings take place every 3 months. Working groups may meet more frequently as needed.
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Publications
Publications on behalf of the I4 section
- Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials. Henry CJ, Semova G, Barnes E, Cotter I, Devers T, Rafaee A, Slavescu A, Cathain NO, McCollum D, Roche E, Mockler D, Allen J, Meehan J, Klingenberg C, Latour JM, van den Hoogen A, Strunk T, Giannoni E, Schlapbach LJ, Degtyareva M, Plötz FB, de Boode WP, Naver L, Wynn JL, Küster H, Janota J, Keij FM, Reiss IKM, Bliss JM, Polin R, Koenig JM, Turner MA, Gale C, Molloy EJ; Infection, Inflammation, Immunology and Immunisation (I4) section of the European Society for Paediatric Research (ESPR). Pediatric Research. 2022
- Ryan L, van den Hoogen A, Latour J, Plotz F, Degtyareva M, Keuning M, Klingenberg K, Giannoni E, Reiss E, Roehr C, Gale C, Molloy E. "Neonates and COVID-19 Review: State of the Art." Pediatric Research. 2022
- Hayes R, Hartnett J, Semova G, Murray C, Murphy K, Carroll L, Plapp H, Hession L, O'Toole J, McCollum D, Roche E, Jenkins E, Mockler D, Hurley T, McGovern M, Allen J, Meehan J, Plötz FB, Strunk T, de Boode WP, Polin R, Wynn JL, Degtyareva M, Küster H, Janota J, Giannoni E, Schlapbach LJ, Keij FM, Reiss IKM, Bliss J, Koenig JM, Turner MA, Gale C, Molloy EJ; Infection, Inflammation, Immunology and Immunisation (I4) section of the European Society for Paediatric Research (ESPR). "Neonatal sepsis definitions from randomised clinical trials." Pediatric Research. 2021
- Molloy EJ, Wynn JL, Bliss J, Koenig JM, Keij FM, McGovern M, Kuester H, Turner MA, Giannoni E, Mazela J, Degtyaeva M, Strunk T, Simons S, Janota J, Plotz FB, van den Hoogen A, de Boode W, Schlapbach LJ, Reiss I. "Neonatal sepsis: Need for consensus definition, collaboration and core outcomes." Pediatric Research. 2020
- McGovern M, Giannoni E, Kuester H, Turner MA, van den Hoogen A, Bliss JM, Koenig JM, Keij FM, Mazela J, Finnegan R, Degtyareva M, Simons SHP, de Boode WP, Strunk T, Reiss IKM, Wynn JL, Molloy EJ; Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR. "Challenges in developing a consensus definition of neonatal sepsis." Pediatric Research. 2020
Publications based on collaborative research including I4 section members
- Stocker M, Klingenberg C, Navér L, Nordberg V, Berardi A, El Helou S, Fusch G, Bliss JM, Lehnick D, Dimopoulou V, Guerina N, Seliga-Siwecka J, Maton P, Lagae D, Mari J, Janota J, Agyeman PKA, Pfister R, Latorre G, Maffei G, Laforgia N, Mózes E, Størdal K, Strunk T, Giannoni E. "Less is more: Antibiotics at the beginning of life." Nature Communications, 2023.
- Giannoni E, Dimopoulou V, Klingenberg C, Navér L, Nordberg V, Berardi A, el Helou S, Fusch G, Bliss J, Lehnick D, Guerina N, Seliga-Siwecka J, Maton P, Lagae D, Mari J, Janota J, Agyeman P, Pfister R, Latorre G, Maffei G, Laforgia N, Mózes E, Størdal K, Strunk T, Stocker M, for the AENEAS study group. Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America and Australia. JAMA Network Open. 2022
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How to engage with us
Please contact the ESPR Secretariat via office@espr.eu. We will be more than happy to forward your request to the members of the Infection, Inflammation, Immunology and Immunisation (I4) Section.